Novel Prion Protein in BSE-affected Cattle, Switzerland
نویسندگان
چکیده
Acknowledgments We thank André Luiz Correa de Sousa, Márcia Leão, and Anna Elizabeth Martins Alves for collecting the samples and data from the patients; Sabrina Sampaio Bandeira for the patient impairment evaluation; Domingos Diniz, Miguel Canto, and the Programa de Ação Interdisciplinar at Oriximiná for logistical support and fruitful discussions; John Spencer for supplying the native PGL-I and technical support with the ELISA; the Oriximiná health secretary and community health agents; and the study participants.
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Polymorphism of Prion Protein Gene (PRNP) in Iranian Holstein and Two Local Cattle Populations (Golpayegani and Sistani) of Iran
Bovine spongiform encephalopathy (BSE) is a fatal infectious neurodegenerative disease in cattle, characterized by the accumulation of an abnormal, proteaseresistant prion protein (PrPSc) in the brain. BSE is similar to scrapie in sheep and goats and Creuzfeldt-Jakob disease in humans. Susceptibility in cattle hasbeen shown to be under the influence of two polymorphic locations, which are...
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